Original Contribution Age-related Changes in Mammographic Density and Breast Cancer Risk
نویسندگان
چکیده
High mammographic density is a strong breast cancer risk factor. Density normally declines with aging. We investigated whether the level of decline in mammographic density is related to breast cancer risk using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Prospect cohort. This cohort was recruited among participants of a population-based breast cancer screening program in the Netherlands between 1993 and 1997. We examined whether age-related changes in mammographic density were different for 533 cases and 1,367 controls who were 49–69 years of age at the time of recruitment into the cohort. We used mixed models with linear and quadratic terms for age and interaction terms between age terms and case status. The percent mammographic density at the first available mammogram was higher for cases than for controls (25.2% vs. 22.5%) (P = 0.003). The average decline in density over 10 years was 11% in both cases and controls (P = 0.56). When studying changes among 4 categories of density, we saw some indication that large changes may influence breast cancer risk. Although no difference was seen in the average decline, we cannot exclude that large changes may influence breast cancer risk.
منابع مشابه
Investigating the Factors Affecting the Mammographic Density of Breast Tissue in Patients Referred to the Breast Cancer Research Center, Iran
Introduction: Of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. On the other hand, increasing the breast tissue density leads to increased risk of breast cancer. Various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...
متن کاملInvestigating the Factors Affecting the Mammographic Density of Breast Tissue in Patients Referred to the Breast Cancer Research Center, Iran
Introduction: Of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. On the other hand, increasing the breast tissue density leads to increased risk of breast cancer. Various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...
متن کاملAge-related changes in mammographic density and breast cancer risk.
High mammographic density is a strong breast cancer risk factor. Density normally declines with aging. We investigated whether the level of decline in mammographic density is related to breast cancer risk using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Prospect cohort. This cohort was recruited among participants of a population-b...
متن کاملMammographic Parenchymal Patterns and Breast Cancer Risk: Considering BMI, CBT and Age of Women in Tabriz, Iran
Mammography is a well-accepted diagnostic technique for the early detection of breast cancer and has been shown to reduce the breast cancer mortality rate in women who are 40-69 years old Boonlikit (2013). Some studies explained age and race related changes in mammographic parenchymal patterns (Zulfiqar et al., 2011). The radiology appearance of the female breast varies from completely fatty to...
متن کاملChanges in mammographic density over time in breast cancer cases and women at high risk for breast cancer
High mammographic breast density is one of the strongest intermediate markers of breast cancer risk, and decreases in density over time have been associated with decreases in breast cancer risk. Using repeated measures of mammographic density in a cohort of high-risk women, the Women at Risk (WAR) cohort at Columbia University Medical Center (N = 2670), we examined whether changes in prediagnos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013